Symbol
Name
ID

Rad50
RAD50 double strand break repair protein
MGI:109292

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

abnormal thymus morphology

spleen hyperplasia

decreased immature B cell number

increased late pro-B cell number

decreased pro-B cell number

decreased double-negative T cell number

decreased B cell number

decreased pre-B cell number

decreased T cell number

decreased macrophage cell number

increased macrophage cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal spleen morphology

decreased IgE level

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal immune system cell morphology

abnormal immune system organ morphology

decreased interferon-gamma secretion

decreased interleukin-13 secretion

increased interleukin-13 secretion

decreased interleukin-4 secretion

increased interleukin-4 secretion

decreased interleukin-5 secretion

increased interleukin-5 secretion

decreased inflammatory response

Availability

Mouse Genotype

Rad50^tm1Flv/Rad50^tm1Flv

Rad50^tm2.1Flv/Rad50^tm2.1Flv

Rad50^tm2Jpt/Rad50^tm2Jpt

Rad50^tm3.1Flv/Rad50^tm3.1Flv

Rad50^tm4.1Flv/Rad50^tm4.1Flv

Rad50^tm2.1Flv/Rad50^tm2.2Flv
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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